CausalCCC

FROM CELL-CELL COMMUNICATION METHODS TO INTEGRATIVE CAUSAL PATHWAYS

schema of an causalCCC network

Create your causalCCC network

from your Single-Cell object
schema of an causalCCC network
schema of an causalCCC network

1. Get your CCC links

  • using your own Ligand-Receptor list
  • using our easy integration of LIANA pipeline (multiple Cell-Cell Communication methods available)
schema of an causalCCC network

2. Get your upstream and downstream genes

  • using your own upstream and downstream gene list
  • using CausalCCC feature selection tool

3. Get your input files

Filter your single-cell object or use our wrapper function for seamless upload (CSV, Seurat, Anndata ...)

my_files <- causalCCC.wrapper(SeuratObject)

Image Description
Image Description

4. Run causalCCC

See publication here : paper
See tutorials here : tutorial


CausalCCC offers an interactive webserver solution to reconstruct gene interaction pathways across interacting cell types, downstream of the usual processing of single-cell RNAseq objects. This allows you to keep total control of your single-cell object. See tutorials.

See publication here : paper
See detailed CausalCCC best practice here : tutorial