FROM CELL-CELL COMMUNICATION METHODS TO INTEGRATIVE CAUSAL PATHWAYS
CausalCCC reconstructs gene interaction pathways across interacting cell types from single-cell transcriptomic data.
CausalCCC integrates a robust causal discovery method (MIIC) with Cell-Cell Communication (CCC) methods to reconstruct intracellular networks upstream and downstream of Ligand-Receptor pairs.
Try out CausalCCC with the demo dataset here (documentation and tutorials are available here)